2 edition of role of peroxisomal metabolism in rodent models of obesity. found in the catalog.
role of peroxisomal metabolism in rodent models of obesity.
by The Polytechnic, Wolverhampton, School of Applied Sciences, 1986. in Wolverhampton
Written in English
Thesis (Ph.D) - The Polytechnic, Wolverhampton (CNAA), 1985.
Peroxisome proliferator-activated receptors (PPARs) are transcription factors that play an important role in the regulation of genes involved in lipid utilization and storage, lipoprotein metabolism, adipocyte differentiation, and insulin action. The three isoforms of the PPAR family, i.e. α, δ, and γ, have distinct tissue distribution. Dietary lipids and metabolic syndrome. MS, also known as syndrome X, or the insulin resistance syndrome, is a combination of medical disorders comprising an array of metabolic risk factors including central obesity, dyslipidemia, hypertension, glucose intolerance, and insulin resistance.The worldwide prevalence of MS causes lots of health problems not only in the developed countries Cited by: 3.
In conclusion, our studies reveal a novel role of D2 and peroxisomes in the protection from disruptions of lipid metabolism induced by dietary erucic acid and that D2 resides in a unique compartment within adipocytes that plays a yet to be elucidated role in the regulation of lipid : Jingjing Liu. Defects in the enzyme are associated with a severe disorder of peroxisomal fatty acid metabolism in humans (Ferdinandusse et al. ). R-HSA (Reactome) Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,3-dehydrohexacosanoyl-CoA and H2O to form 3-hydroxyhexacosanoyl-CoA.
Metabolic syndrome is characterized by a combination of risk factors for cardiovascular disease and diabetes that are generally linked to insulin resistance and central obesity .Cardiovascular disease is the leading cause of morbidity and mortality in the world ; therefore, the study of metabolic syndrome as a predictor of cardiovascular problems is by: In man, elevated levels of plasma lipoprotein (a)(Lp(a)) is a cardiovascular risk factor, and oxidized phospholipids are believed to play a role as modulators of inflammatory processes such as atherosclerosis. Polyamines are potent antioxidants and anti-inflammatory agents. It was therefore of interest to examine polyamines and their metabolism in LPA transgenic by: 1.
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Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance Article (PDF Available) in AJP Endocrinology and Metabolism (4):EE November with. The peroxisome proliferator-activated receptors (PPARs) are a set of three nuclear hormone receptors that together play a key role in regulating metabolism, particularly the switch between the fed and fasted state and the metabolic pathways involving fatty-acid oxidation and lipid by: Peroxisomal lipid metabolism.
they are known to contain more than 50 enzymes, more than half of which play a role in lipid metabolism.
During the past two decades, considerable knowledge has been gained about the role of peroxisomes in lipid metabolism, the implications of induction of hepatic peroxisome proliferation and the peroxisomal Cited by: To investigate the role of hepatic energy metabolism in metabolically healthy humans, our research group examined 76 middle-age humans by combining oral glucose tolerance tests with liver 31 P-MRS.
79 After adjustment for age, sex, and body mass, hepatic ATP and Pi related to postglucose challenge glycemia and Pi as well as FFA, but not with Author: Hisayuki Katsuyama, Juliane K.
Czeczor, Michael Roden. In turn, lipid metabolism could be an important modifier of the time-of-onset and severity in Wilson’s disease. Work over several decades has yielded physiological and biochemical data on the consequences of copper deficiency, particularly with respect to lipid metabolism, in rodent by: In mammals, white adipose tissue functions as the main depot for fuel storage.
In the past decade, identification of myriad lipid and protein signals secreted from this tissue has led to its recognition as a major endocrine organ (Rondinone, ; Trayhurn and Bing, ).This was principally based on the discovery of leptin, a cytokine-like hormone secreted from white adipose tissue in.
To date, investigations targeted at elucidating the role of peroxisomes in diabetes have been performed primarily in rodent models of type 1 diabetes and generally indicate elevated peroxisomal β-oxidative capacity (4, 15–17, 33, 42, 44, 60, 72). Although the clinical manifestations of type 1 and type 2 diabetes are similar, the Cited by: Peroxisomal oxidation yields metabolites that are more efficiently utilized by mitochondria.
This is of potential clinical importance because reduced fatty acid oxidation is suspected to promote ex Cited by: Peroxisomes play an essential role in human metabolism. • Peroxisomes are involved in multiple catabolic and anabolic metabolic pathways.
• Peroxisomal single enzyme deficiencies affect specific metabolic pathways. • Peroxisome biogenesis disorders affect the assembly and maintenance of peroxisomes and multiple metabolic by: There are key components to the metabolic syndrome which include in addition to insulin resistance (the hallmark feature of the syndrome), hypertension, dyslipidemia, chronic inflammation, impaired fibrinolysis, procoagulation, and most telling, central obesity.
The role of adipose tissue (fat) stems from the fact that the organ is active at. The incidence of obesity and its comorbidities, such as insulin resistance and type II diabetes, are increasing dramatically, perhaps caused by the change in the fatty acid composition of common human diets.
Adipose tissue plays a role as the major energy reservoir in the body. An excess of adipose mass accumulation caused by chronic positive energy balance results in by: Peroxisome dysfunction in peroxisomal biogenesis disorders of human patients and animal models will disrupt lipid metabolism including fatty acid (FA) oxidation, leading to elevated levels of.
Peroxisomes, which are widely distributed in mammalian tissues, carry out several important functions in cellular metabolism. Production of alkylglycerolphosphate, a key intermediate in the synthesis of plasmalogens and other ether lipids, occurs in the peroxisome.
A fatty acid β-oxidation system with significant differences from mitochondrial β-oxidation is also found in the peroxisomes Cited by: While rodent models can only reproduce certain aspects of human diseases, they remain useful tools in our examination of the mechanisms contributing to the development of MetS.
This chapter will provide a brief review of some of the more common mouse and rat MetS : David Sanchez-Infantes, Carrie M. Elks, Jacqueline M. Stephens. In addition, the central role demonstrated for PPARδ in muscle lipid metabolism can open new therapeutic strategies for the treatment of obesity and type 2 diabetes, either by the direct use of PPARδ agonists, as already demonstrated in animal models, or through drugs related to its downstream effects, in a way that mimics what is happening Cited by: The rat is a widely-used model for human biology, but we must be aware of metabolic differences.
Here, the authors reconstruct the genome-scale metabolic network of Cited by: THE METABOLIC SYNDROME: RELATIONSHIP BETWEEN INSULIN SENSITIVITY AND THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARs) IN SACCHARIDE AND LIPID METABOLISM Rabha Ben Yahiaa, Radka Lichnovskáa, Tomáš Brychtab a Institute of Physiology, Faculty of Medicine, Palacký University, 15 Olomouc, Czech Republic.
Their important role in lipid metabolism as well as in health and disease became obvious in the s, when the major function of peroxisomes in the β-oxidation of very-long-chain fatty acids (VLCFA) and in the biosynthesis of ether glycerolipids (plasmalogens).
Anne Silcox has written: 'The role of peroxisomal metabolism in rodent models of obesity' Asked in Economics How did economics play a role in European colonies in the 19th century.
Visceral fat accumulation is one of the most important predictors of mortality in obese populations. Administration of green tea extract (GTE) can reduce body fat and reduce the risk of obesity-related diseases in mammals.
In this study, we investigated the effects and mechanisms of GTE on adiposity in diet-induced obese (DIO) zebrafish. Zebrafish at to months post-fertilization were Cited by:.
The peroxisome proliferator-activated receptors (PPARs) are a set of three nuclear hormone receptors that together play a key role in regulating metabolism, particularly the switch between the fed and fasted state and the metabolic pathways involving fatty-acid oxidation and lipid metabolism.
In addition, they have a number of important developmental and regulatory roles outside metabolism.monitor changes in metabolism at different stages of inducement of obesity and the MetS in rats, it is appropriate to use a combined high-fat and high-fructose diet.
Key words: Obesity, metabolic syndrome, rats, dietary models A REVIEW ON THE MODELS OF OBESITY AND METABOLIC SYNDROME IN RATS The Metabolic Syndrome (MetS) is a socially.In rodent models of diet-induced obesity (DIO), increased inflammatory signaling in the mediobasal hypothalamus (MBH) similarly contributes to leptin resistance and weight gain (7 – 12), but the cellular interactions underlying this inflammatory response remain uncharacterized.
The goal of the current study was to identify the neuroanatomical Cited by: